rnase p การใช้

• The ncRNA RNase P has also been shown to influence gene expression.
• Several types of ribozyme motifs exist, including group II, and RNase P ribozymes.
• RNA was further resolved into tmRNA and the similarly-sized RNase P RNA ( 10Sb ).
• RNase P exerts its role in transcription through association with Pol III and chromatin of active tRNA and 5S rRNA genes.
• The Pyrobaculum and Caldivirga RNase P RNAs are the smallest naturally occurring form yet discovered to function as trans-acting ribozymes.
• These RNA fossils include the ribosome itself ( in which RNA catalyses peptide-bond formation ), the modern ribozyme catalyst RNase P, and tRNAs.
• Sidney Altman and Thomas Cech first discovered catalytic RNA molecules, RNase P and group II intron ribozymes, in 1989 and won the Nobel Prize for their discovery.
• In the human nucleus RNase P is required for the normal and efficient transcription of various ncRNAs transcribed by RNA polymerase III . These include tRNA, U6 snRNA genes.
• The structures of protein subunits of archaeal RNase P have been resolved by x-ray crystallography and NMR, thus revealing new protein domains and folding fundamental for function.
• It has recently been argued that the archaebacteriium " Nanoarchaeum equitans " does not possess RNase P . Computational and experimental studies failed to find evidence for its existence.
• The 6S RNA binds to RNA polymerase and regulates signal recognition particle ( SRP ), which is required for the secretion of proteins and RNase P is involved in maturing tRNAs.
• In this organism the tRNA promoter is close to the tRNA gene and it is thought that transcription starts at the first base of the tRNA thus removing the requirement for RNase P.
• Originally, it was believed that, in the bacterial RNase P complex, the protein subunit was responsible for the catalytic activity of the complex, which is involved in the maturation of tRNAs.
• Vault RNAs are not the only kind of RNA with this type of semi-conserved / highly variable structure, other notable RNA s include RNAse P, RNAse MRP, and 7SK RNA.
• Although the RNase P complex also exists in eukaryotic organisms, his later work revealed that in those organisms, the protein subunits of the complex are essential to the catalytic activity, in contrast to the bacterial RNase P.
• Although the RNase P complex also exists in eukaryotic organisms, his later work revealed that in those organisms, the protein subunits of the complex are essential to the catalytic activity, in contrast to the bacterial RNase P.
• The last ribozyme motif, the RNase P ribozyme, is found in " Escherichia coli " and is known for its ability to cleave the phosphodiester bonds of several tRNA precursors when joined to a protein cofactor.
• It has been shown that human nuclear RNase P is required for the normal and efficient transcription of various U6 snRNA genes, which are transcribed by RNA polymerase III, one of three major nuclear RNA polymerases in human cells.
• In molecular biology, nuclear ribonuclease P ( RNase P ) is a ubiquitous homologous-- the helices corresponding to P1, P2, P3, P4, and P10 / 11 are common to all cellular RNase P RNAs.
• In molecular biology, nuclear ribonuclease P ( RNase P ) is a ubiquitous homologous-- the helices corresponding to P1, P2, P3, P4, and P10 / 11 are common to all cellular RNase P RNAs.